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a LANGE medical book
Pharmacology
Examination
& Board Review
Eleventh Edition
Katzung & Trevor’s
Anthony J. Trevor, PhD
Professor Emeritus of Pharmacology and Toxicology
Department of Cellular & Molecular Pharmacology
University of California, San Francisco
Bertram G. Katzung, MD, PhD
Professor Emeritus of Pharmacology
Department of Cellular & Molecular Pharmacology
University of California, San Francisco
Marieke Kruidering-Hall, PhD
Associate Professor & Academy Chair of Pharmacology Education
Department of Cellular & Molecular Pharmacology
University of California, San Francisco
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Notice
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Contents
Preface
v
part
I
1
part
IV
BASIC PRINCIPLES
1.
Introduction 1
DRUGS WITH IMPORTANT ACTIONS
ON SMOOTH MUSCLE 143
16.
Histamine, Serotonin, & the Ergot
Alkaloids 143
17.
Vasoactive Peptides
152
2.
Pharmacodynamics 16
3.
Pharmacokinetics 26
4.
Drug Metabolism 35
5.
Pharmacogenomics 41
part
18.
Prostaglandins & Other Eicosanoids 158
19.
Nitric Oxide, Donors, & Inhibitors 165
20.
Drugs Used in Asthma & Chronic
Obstructive Pulmonary Disease 169
II
47
AUTONOMIC DRUGS
part
V
6.
Introduction to Autonomic Pharmacology 47
7.
Cholinoceptor-Activating
& Cholinesterase-Inhibiting Drugs 60
8.
Cholinoceptor Blockers & Cholinesterase
Regenerators 69
9.
Sympathomimetics 76
10.
Adrenoceptor Blockers 85
part
DRUGS THAT ACT IN THE CENTRAL
NERVOUS SYSTEM 179
21.
Introduction to CNS Pharmacology 179
22.
Sedative-Hypnotic Drugs 186
23.
Alcohols
194
24.
Antiseizure Drugs 201
25.
General Anesthetics
208
III
93
CARDIOVASCULAR DRUGS
26.
Local Anesthetics
216
11.
Drugs Used in Hypertension 93
12.
Drugs Used in the Treatment of Angina
Pectoris 103
13.
Drugs Used in Heart Failure 112
14.
Antiarrhythmic Drugs 121
15.
Diuretics & Other Drugs That Act on the
Kidney 132
27.
Skeletal Muscle Relaxants 221
28.
Drugs Used in Parkinsonism & Other
Movement Disorders 229
29.
Antipsychotic Agents & Lithium 236
30.
Antidepressants
244
31.
Opioid Analgesics & Antagonists 252
32.
Drugs of Abuse 260
iii
iv
CONTENTS
part
VI
47.
Antimycobacterial Drugs
48.
Antifungal Agents
395
389
DRUGS WITH IMPORTANT ACTIONS
ON BLOOD, INFLAMMATION,
& GOUT 267
33.
Agents Used in Cytopenias; Hematopoietic
Growth Factors 267
34.
Drugs Used in Coagulation Disorders 276
35.
Agents Used in Dyslipidemia 288
36.
NSAIDs, Acetaminophen, & Drugs Used in
Rheumatoid Arthritis & Gout 296
part
49.
Antiviral Chemotherapy & Prophylaxis 402
50.
Miscellaneous Antimicrobial Agents
& Urinary Antiseptics 414
51.
Clinical Use of Antimicrobials 420
52.
Antiprotozoal Drugs
426
53.
Antihelminthic Drugs 434
54.
Cancer Chemotherapy
55.
Immunopharmacology
part
440
452
VII
307
ENDOCRINE DRUGS
IX
463
TOXICOLOGY
37.
Hypothalamic & Pituitary Hormones 307
38.
Thyroid & Antithyroid Drugs 316
39.
Corticosteroids & Antagonists 322
40.
Gonadal Hormones & Inhibitors 329
41.
Pancreatic Hormones, Antidiabetic Agents,
& Glucagon 340
42.
Drugs That Affect Bone Mineral
Homeostasis 349
part
56.
Environmental & Occupational
Toxicology 463
57.
Heavy Metals
469
58.
Management of the Poisoned Patient 475
part
X
483
SPECIAL TOPICS
59.
Drugs Used in Gastrointestinal
Disorders 483
VIII
359
CHEMOTHERAPEUTIC DRUGS
60.
Dietary Supplements & Herbal
Medications 492
61.
Drug Interactions
497
43.
Beta-Lactam Antibiotics & Other Cell Wall
Synthesis Inhibitors 360
44.
Chloramphenicol, Tetracyclines,
Macrolides, Clindamycin, Streptogramins,
& Linezolid 369
45.
Aminoglycosides
377
Appendix I.
Strategies for Improving Test
Performance 503
Appendix II.
Key Words for Key Drugs 506
Appendix III.
Examination 1
Appendix IV.
Examination 2
Index
518
534
46.
Sulfonamides, Trimethoprim, &
Fluoroquinolones 382
549

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