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Textbook of Clinical Neuropsychiatry
and Behavioral Neuroscience
Textbook of Clinical
Neuropsychiatry and Behavioral
Neuroscience
Third edition
David P Moore
MD
Associate Clinical Professor, Department of Psychiatry and Behavioral Sciences; and
Associate Clinical Professor, Department of Neurosurgery (Division of Physical
Medicine and Rehabilitation), University of Louisville School of Medicine, Kentucky,
USA
Basant K Puri
MA, PhD, MB, BChir, FRCPsych, MMath
Hammersmith Hospital and Imperial College London, UK
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
© 2012 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
Version Date: 20130508
International Standard Book Number-13: 978-1-4441-6494-7 (eBook - PDF)
This book contains information obtained from authentic and highly regarded sources. While all reasonable efforts have been made to publish reli-
able data and information, neither the author[s] nor the publisher can accept any legal responsibility or liability for any errors or omissions that
may be made. The publishers wish to make clear that any views or opinions expressed in this book by individual editors, authors or contributors are
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Dedication
This book is dedicated to our families and to the patients who have entrusted us with their care. We also wish to express
our gratitude to Professors Jeffrey Cummings and Michael Trimble, whose kind words have made this third edition
possible, and Dr Moore wishes to add, as he has in the first two editions, a special thanks to James W Jefferson, MD, for
whose example and guidance he remains forever grateful.
‘Scribere actum fidei est’
Contents
Preface
xv
PART I
NEUROSCIENCE FUNDAMENTALS
1
Neuroscience fundamentals
1.1
1.2
1.3
1.4
1.5
1.6
1.7
Functional neuroanatomy
Functional neuroimaging
Neuropsychology
Neurophysiology
Molecular genetics
Psychoneuroendocrinology
Immunology
1
3
3
27
31
43
45
50
55
PART II
DIAGNOSTIC ASSESSMENT
2
Diagnostic assessment
2.1
2.2
2.3
2.4
2.5
2.6
Diagnostic interview
Mental status examination
Neurologic examination
Clinical neuroimaging
Electroencephalography
Lumbar puncture
63
65
65
67
72
78
81
92
PART III
3
SIGNS, SYMPTOMS, AND SYNDROMES
101
103
103
107
108
108
109
110
110
113
114
120
128
128
130
132
‘Cortical’ signs and symptoms
3.1
3.2
3.3
3.4
3.5
3.6
3.7
3.8
3.9
3.10
Aphasia
Alexia
Agraphia
Acalculia
Gerstmann’s syndrome
Hypergraphia
Aprosodia
Apraxia
Agnosias
Neglect
4
Abnormal movements
4.1 Tremor
4.2 Myoclonus
4.3 Motor tics

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