D.Wemmer - The Molecules of Life Physical and Chemical Principles.pdf

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The
MOLECULES
of LIFE
Physical and Chemical Principles
This page is intentionally left blank.
The
MOLECULES
of LIFE
Physical and Chemical Principles
John Kuriyan
Boyana Konforti
David Wemmer
Garland Science
Vice President: Denise Schanck
Editor: Summers Scholl
Senior Editorial Assistant: Kelly O’Connor
Primary Illustrator: Lore Leighton
Additional Illustration: Laurel Muller, Cohographics, and Tiago Barros
Production Editor and Layout: EJ Publishing Services
Cover and Text Design: Matthew McClements, Blink Studio, Ltd.
Developmental Editors: Sherry Granum Lewis, John Murdzek, and
Miranda Robertson
Copyeditor: John Murdzek
Proofreader: Sally Huish
Indexer: Merrall-Ross International Ltd.
The cover illustration shows the bacterial ribosome (purple and
gray)
in the act of decoding the sequence of a messenger RNA molecule
(blue). Three tRNA molecules are bound to the ribosome (red,
green,
and
yellow).
The growing protein chain, which is hidden within the
ribosome, is attached to the
green
tRNA. The
red
tRNA is delivering
a new amino acid for incorporation into the protein, and the
yellow
tRNA is about to depart. (Based on X-ray crystallographic analysis by
V. Ramakrishnan and colleagues at the MRC Laboratory of Molecular
Biology, Cambridge, UK. )
JOHN KURIYAN is Professor of Molecular and Cell Biology and of
Chemistry at the University of California, Berkeley. His laboratory
uses x-ray crystallography to determine the three-dimensional
structures of proteins involved in signaling and replication, as well as
biochemical, biophysical, and computational analyses to elucidate
mechanisms. Kuriyan was elected to the US National Academy of
Sciences in 2001.
BOYANA KONFORTI is the launch Editor of Cell Reports, an open-
access journal that covers all of biology with a focus on short papers.
Over her career, Konforti has researched the mechanisms of DNA
recombination and RNA splicing. She has been a professional editor
for over 13 years; most recently she was Chief Editor of Nature
Structural & Molecular Biology.
DAVID WEMMER is Professor of Chemistry at the University of
California, Berkeley and has served as Vice Chair, Assistant Dean,
and Executive Associate Dean since joining the faculty in 1985. His
research in structural biology uses magnetic resonance methods
to investigate the structure of proteins and DNA toward a better
understanding of how these molecules function. Wemmer is a Fellow
of the AAAS and a member of Phi Kappa Phi and Sigma Xi.
© 2013 by Garland Science, Taylor & Francis Group, LLC
This book contains information obtained from authentic and highly
regarded sources. Every effort has been made to trace copyright holders
and to obtain their permission for the use of copyright material. Reprinted
material is quoted with permission, and sources are indicated. A wide
variety of references are listed. Reasonable efforts have been made to
publish reliable data and information, but the author and the publisher
cannot assume responsibility for the validity of all materials or for the
consequences of their use. All rights reserved. No part of this publication
may be reproduced, stored in a retrieval system or transmitted in any
form or by any means—graphic, electronic, or mechanical, including
photocopying, recording, taping, or information storage and retrieval
systems—without permission of the copyright holder.
ISBN 978-0-8153-4188-8
Library of Congress Cataloging-in-Publication Data
Kuriyan, John.
The molecules of life : physical and chemical principles / John Kuriyan,
Boyana Konforti, David Wemmer.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-0-8153-4188-8 (alk. paper)
I. Konforti, Boyana. II. Wemmer, David. III. Title.
[DNLM: 1. Molecular Biology--methods. 2. Biochemical Processes--
physiology. 3. Genomics--methods. QH 506]
572’33--dc23
.
2012008865
Published by Garland Science, Taylor & Francis Group, LLC,
an informa business, 711 Third Avenue, New York, NY 10017,
USA, and 3 Park Square, Milton Park, Abingdon, OX14 4RN, UK.
Printed in the United States of America
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