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AUTOIMMUNE DISEASES
CONTRIBUTING FACTORS,
SPECIFIC CASES OF
AUTOIMMUNE DISEASES,
AND
STEM
CELL
AND
OTHER THERAPIES
Edited by James Chan
AUTOIMMUNE
DISEASES – CONTRIBUTING
FACTORS, SPECIFIC
CASES OF AUTOIMMUNE
DISEASES, AND STEM CELL
AND OTHER THERAPIES
Edited by James Chan
Autoimmune Diseases – Contributing Factors,
Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies
http://dx.doi.org/10.5772/2896
Edited by James Chan
Contributors
Marcus Muller, Rachael Terry, Stephen D. Miller, Daniel R. Getts, Ahmad Massoud, Amir
Hossein Massoud, Nicola Gagliani, Samuel Huber, Dan Li, Miranda Piccioni, Zhimei Gao, Chen
Chen, Zuojia Chen, Jia Nie, Zhao Shan, Yangyang Li, Andy Tsun, Bin Li, Reginald Halaby, Alla
Arefieva, Marina Krasilshchikova, Olga Zatsepina, Anna Pituch-Noworolska, Katarzyna
Zwonarz, J.P.S. Peron, D. Oliveira, W. N. Brandão, A. Fickinger, A. P. Ligeiro de Oliveira, L. V.
Rizzo, N.O.S. Câmara, Reuben Mari Valenzuela, Paayal Patel, Jorge C. Kattah, Marco Wiltgen,
Gernot P. Tilz, Eun Wha Choi, Jesus Ciriza, Jennifer O. Manilay, Rizwanul Haque, Fengyang Lei,
Jianxun Song, Katerina Chatzidionysiou, A.A. Baranov, E.I. Alexeeva, L.S. Namazova-Baranova,
T.M. Bzarova, S.I. Valiyeva, R.V. Denisova, K.B. Isayeva, A.M. Chomakhidze, E.G. Chistyakova,
T.V. Sleptsova, E.V. Mitenko, E.I. Zelikovich, G.V. Kurilenko, E.L. Semikina, A.V. Anikin, A.M.
Stepanchenko, N.I. Taybulatov, A.V. Starikova, I.V. Dvoryakovskiy, M.V. Ryazanov
Published by InTech
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Copyright © 2012 InTech
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Notice
Statements and opinions expressed in the chapters are these of the individual contributors and
not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy
of information contained in the published chapters. The publisher assumes no responsibility for
any damage or injury to persons or property arising out of the use of any materials,
instructions, methods or ideas contained in the book.
Publishing Process Manager
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Typesetting
InTech Prepress, Novi Sad
Cover
InTech Design Team
First published July, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from orders@intechopen.com
Autoimmune Diseases – Contributing Factors, Specific Cases of
Autoimmune Diseases, and Stem Cell and Other Therapies, Edited by James Chan
p. cm.
ISBN 978-953-51-0693-7
Contents
Preface IX
Section 1
Chapter 1
Pathogenesis of Autoimmune Disease
1
Current Theories for Multiple
Sclerosis Pathogenesis and Treatment 3
Marcus Muller, Rachael Terry,
Stephen D. Miller and Daniel R. Getts
Immunologic and Genetic
Factors in Type 1 Diabetes Mellitus 25
Ahmad Massoud and Amir Hossein Massoud
Balancing Pro- and Anti-Inflammatory
CD4+ T Helper Cells in the Intestine 51
Nicola Gagliani and Samuel Huber
T Cell Metabolism in Autoimmune Diseases 77
Dan Li, Miranda Piccioni, Zhimei Gao, Chen Chen,
Zuojia Chen, Jia Nie, Zhao Shan, Yangyang Li, Andy Tsun and Bin Li
Apoptosis and Autoimmune Disorders
Reginald Halaby
Specific Autoimmune Diseases
117
99
Chapter 2
Chapter 3
Chapter 4
Chapter 5
Section 2
Chapter 6
Immune Complex Deposits as a
Characteristic Feature of Mercury-Induced SLE-Like
Autoimmune Process in Inbred and Outbred Mice 119
Alla Arefieva, Marina Krasilshchikova and Olga Zatsepina
Celiac and Inflammatory Bowel Diseases in
Children with Primary Humoral Immunodeficiency
Anna Pituch-Noworolska and Katarzyna Zwonarz
Chapter 7
151
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