Textbook of Anaesthesia.pdf

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Smith and Aitkenhead's Textbook of
Anaesthesia
SIXTH EDITION
Alan R. Aitkenhead
Emeritus Professor of Anaesthesia, Division of Anaesthesia and Intensive Care, Queen's Medical
Centre, Nottingham, UK
Iain K. Moppett
Associate Professor and Honorary Consultant, Division of Anaesthesia and Intensive Care,
Queen's Medical Centre, Nottingham, UK
Jonathan P. Thompson
Senior Lecturer/Hon Consultant in Anaesthesia and Critical Care, University of Leicester and
UHL NHS Trust, Leicester Royal Infirmary, Leicester, UK
Table of Contents
Cover image
Title page
Copyright
Preface
List of Contributors
Chapter 1: General Principles of Pharmacology
HOW DO DRUGS ACT?
THE BLOOD–BRAIN BARRIER AND PLACENTA
PLASMA PROTEIN BINDING
METABOLISM
DRUG EXCRETION
PHARMACOKINETIC PRINCIPLES
PHARMACOGENETICS
METHODS OF DRUG ADMINISTRATION
DRUG INTERACTIONS
VOLATILE ANAESTHETIC AGENTS
Chapter 2: Inhalational Anaesthetic Agents
PROPERTIES OF THE IDEAL INHALATIONAL ANAESTHETIC AGENT
AGENTS IN COMMON CLINICAL USE
AGENTS IN OCCASIONAL USE
ANAESTHETIC GASES
Chapter 3: Intravenous Anaesthetic Agents
BARBITURATES
NON-BARBITURATE INTRAVENOUS ANAESTHETIC AGENTS
INTRAVENOUS MAINTENANCE OF ANAESTHESIA
Chapter 4: Local Anaesthetic Agents
MECHANISM OF ACTION OF LOCAL ANAESTHETICS
THE VOLTAGE-ACTIVATED Na+ CHANNEL
PAIN FIBRES
LOCAL ANAESTHETIC STRUCTURE
PHARMACOLOGICAL PROPERTIES OF LOCAL ANAESTHETICS
DIFFERENTIAL SENSORY AND MOTOR BLOCKADE
PHARMACOKINETICS
CLINICAL PREPARATION OF LOCAL ANAESTHETICS
ENANTIOMER PHARMACOLOGY
INDIVIDUAL LOCAL ANAESTHETIC PHARMACOLOGY
LOCAL ANAESTHETIC TOXICITY
MANAGEMENT OF SEVERE LOCAL ANAESTHETIC TOXICITY
EMERGING LOCAL ANAESTHETIC APPROACHES
Chapter 5: Analgesic Drugs
OPIOIDS
PARACETAMOL
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
COX-2-SPECIFIC INHIBITORS
KETAMINE
Chapter 6: Muscle Function and Neuromuscular Blockade
PHYSIOLOGY OF NEUROMUSCULAR TRANSMISSION
PHARMACOLOGY OF NEUROMUSCULAR TRANSMISSION
REVERSAL AGENTS
NEUROMUSCULAR MONITORING

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